Learn how to coat weapons with deadly poisons in Oblivion Remastered to maximize damage and quickly take down the spongiest of enemies.

Whether you are preparing for a boss fight or getting ready to take down a mob of bandits, poisons provide a serious bonus to your weapon damage in Oblivion Remastered. Any potion with negative effects is considered a poison in the game and cannot be consumed directly.
While Alchemy introduces a variety of poisons with effects ranging from damage over time to paralysis, applying them can be confusing initially. If you’re unsure how to make use of these toxic potions, here’s a clear breakdown of how to coat your weapons with them.
Oblivion Remastered: How To Coat Weapons With Poisons

To begin, open your inventory and locate the poison you want to use. Highlight it and press the left stick on the controller or the R key on the keyboard to bring up the shortcuts menu. Once this wheel appears, assign the poison to a shortcut slot. This will make it easily accessible mid-gameplay, without needing to dig through menus.
Before you apply the poison, ensure the weapon you want to coat is currently equipped in your hand. Now, activate the shortcut wheel—hold LB on Xbox, L1 on PlayStation, or press the R key if using a keyboard. Select the poison you assigned earlier. Once selected, the game will prompt you to confirm if you want to apply the poison to your current weapon. It will even mention the weapon’s name so you can double-check you’ve got the right one. Confirm with “Yes,” and your weapon is now coated.
Keep in mind that poison effects are single-use. For melee weapons, the poison remains active until you land a successful hit. If you miss your target or strike an object like a wall, the poison stays intact. For bows, the poison applies only to the next arrow, regardless of whether it hits or misses. Therefore, aiming your shots carefully after applying a poison is essential.
Best Poisons To Use in Combat

The Alchemy skill is key when making use of poisons in combat. The higher your Alchemy, the greater the potency of your poisons. Here are the best poisons you should be mixing in with your playstyle:
- Damage Health
- Fire Damage
- Paralyze
- Damage Magicka
- Damage Fatigue
The Damage Health potion is the best poison because of its flat damage output and ease of crafting. Some of the most abundant alchemy ingredients have the damage health effect, especially once you get to Apprentice Alchemy rank and unlock the second alchemical effect of ingredients. Once the skill is leveled up enough, you can craft poisons with multiple damage effects, making them fit for taking down bosses.
Thank you for reading the Guide. We provide the latest news and create guides for Baldur’s Gate 3, Enshrouded, Dune Awakening, and more. Also, watch Deltia play games on Twitch or visit his YouTube channel!